CORDIS Project
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This project develops a high-throughput assay to quantify 5-hydroxymethylcytosine, an important epigenetic marker for cancer diagnostics. By combining spectroscopic methods, it aims to improve early cancer detection and monitoring, particularly in colorectal cancer, while being adaptable for other malignancies.
Assay for cancer diagnostics by quantification of 5hmC5-hydroxymethylcytosine (5hmC) is a modified form of the DNA base cytosine and is an important epigenetic marker linked to regulation of gene expression in development and tumorigenesis.
The loss of 5hmC is observed across a wide spectrum of malignant tumours.
The goal of the proposed project is to utilize a novel chemo-enzymatic labelling scheme developed within the framework of my ERC project in order to develop a high-throughput assay capa…
TEL AVIV UNIVERSITY
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