CORDIS Project
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This project investigates the role of specific types of inhibitory interneurons in the limbic system, focusing on their impact on reward-related behaviors using optogenetics and mouse genetics. By understanding how dopamine transmission affects these neurons, the research aims to inform the development of new treatment…
Many psychiatric disorders involve dysfunction of the limbic system that is manifested in a reduced ability to experience pleasure and learning and memory impairment.Dopamine is important in the limbic system, which includes structures such as the nucleus accumbens, ventral tegmental area and prefrontal cortex.
Drugs such as opiates and cocaine, but also antidepressant agents, and deep brain stimulation can possibly recruit certain types of interneurons, whose function is to regulate the firing…
KAROLINSKA INSTITUTET
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