CORDIS Project
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The project aims to understand the infection mechanisms of Legionella bacteria using human lung tissue models. By analyzing the immune response and infection dynamics, it seeks to uncover the molecular processes that lead to Legionnaires’ disease, improving clinical understanding and treatment strategies.
Aging populations and the increasing use of immune modulatory medical treatments have given rise to a growing incidence of opportunistic infections.
Legionella species are Gram-negative environmental bacteria, which after accidental inhalation can cause respiratory infections with symptoms reaching from a mild flu to a severe pneumonia, called Legionnaires’ disease.
Disease progression, i.e. clearance or exacerbation of infection, is determined by the immune status of the host and acute pneumoni…
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