CORDIS Project
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This project investigates how gene expression levels in Escherichia coli affect cellular fitness. By analyzing approximately 4000 genes, it aims to understand the trade-offs between the costs and benefits of protein production, contributing to the broader field of systems biology.
The precise expression of protein coding genes is of crucial importance to all organisms, since proteins are involved in virtually all vital processes.
Some proteins need to be available at exactly the right amount to perform cellular functions sustainably and thereby maximize fitness.
Consequently, gene expression needs to be accurately controlled.
For these reasons, it has been hypothesized that cells evolve towards a state in which expression levels are optimally tuned to maximize fitness in…
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