CORDIS Project
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This project investigates the role of a sperm-specific enzyme in oocyte activation, aiming to improve treatments for male infertility. It focuses on identifying proteins that interact with this enzyme and evaluating the impact of clinical procedures on gamete proteins.
Mammalian sperm activate the oocyte at fertilisation by triggering a calcium-mediated pathway via PLCζ, a sperm-specific phospholipase. PLCζ deficiency is linked to human infertility, a condition that affects 1 in 7 couples.
While intra-cytoplasmic sperm injection (ICSI) can rescue many types of male infertility, 1 – 5% of cases fail due to PLCζ-deficiency.
While artificial activating agents are available, such chemicals do not initiate activation in an endogenous manner.
Recombinant PLCζ thus r…
THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD
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