CORDIS Project
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This project investigates cancer treatment by using genetically engineered mice to toggle tumor suppressor genes on and off. The goal is to identify effective therapeutic targets and understand the role of specific genes like p53 and p73 in cancer therapy and protection from treatment-related injuries.
Cancer is the second cause of death in Europe, after cardiovascular diseases.
These lethal diseases are in desperate need of new therapeutic approaches: despite dramatic advances in the use of conventional chemo and radiotherapy and the growth of more “targeted” drugs, many cancers are still incurable.Cancers are difficult to treat not because they are so mechanistically diverse (indeed, we argue that cancers are not very diverse mechanistically) but because they evolve in response to any pharma…
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