CORDIS Project
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This project develops innovative technologies for rapidly and reversibly inhibiting specific genes in adult mice to better understand gene functions in adult tissues, particularly in the context of cancer. By focusing on oncogenic networks, the research aims to identify potential therapeutic targets for cancer treatmen…
The use of classical, germ-line genetics to define gene function in vertebrates is severely limited by embryonic lethality, developmental compensation and adaptive functional degeneracy, all of which obscure the roles played by genes in adult tissues that would normally have developed in the presence of that gene.
Consequently, classical germ line knock-out technologies provide only limited information as to the roles of genes in adult tissues and their pathologies.
Nowhere is this limitation mo…
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