CORDIS Project
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This project investigates the mechanisms that protect certain cell types from cancer transformation. Using the Drosophila eye epithelium, it aims to explore gene expression differences and the role of long non-coding RNAs in cellular responses to oncogenic signals.
Oncogenesis is a complex multi-step process that involves the combination of genetic and epigenetic alterations for normal cells to turn into cancerous cells.
Remarkably, while some strong oncogenic signals can promote transformation in some cell states, they are completely innocuous to other cell types.My aim is to study this poorly understood phenomena, being my current hypothesis, that intrinsic cell state transformation protection mechanisms are likely to exist.I will use the Drosophila eye…
UNIVERSIDADE DE AVEIRO
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