CORDIS Project
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This project investigates the role of DNA methylation in transcriptional enhancers related to cancer. It aims to identify how changes in enhancer methylation influence gene expression in breast cancer and glioblastoma, potentially leading to new diagnostic and therapeutic strategies.
Cancer is a growing medical problem which genetic and environmental basis is not clearly understood.
Massive efforts over the last decade have identified differences in cancer gene expression that cannot be explained by coding sequences or promoter variations, whereas the effect of transcriptional enhancers remains unclear due to the lack of an effective way to link enhancers with their controlled genes.
Recently, we discovered a class of inter-tumor, inter-patient DNA methylation variations in…
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