CORDIS Project
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This project investigates the oncogenic mechanisms of Acute Myeloid Leukemia driven by specific gene fusions. By analyzing protein interactions and gene expression in various fusion proteins, it aims to identify common pathways that could enhance diagnosis and treatment strategies for this aggressive cancer.
Acute Myeloid Leukemia (AML) is the most frequent cancer of the blood system, with >80% mortality within 5 years of diagnosis.
Straightforward clinical decisions are complicated by the genetic complexity of AML.
In particular, fusion proteins arising from chromosomal aberrations are recurrently found in AML and often act as strong driver oncogenes.
In “Multi-Partner Translocation” (MPT) families, one specific gene is fused to many recipient loci.
Due to this modular architecture, MPT families ar…
VETERINAERMEDIZINISCHE UNIVERSITAET WIEN
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