CORDIS Project
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This project focuses on developing genetically engineered human macrophages for cancer therapy. These macrophages can proliferate, resist tumor-induced changes, and effectively target solid tumors, aiming to improve treatment outcomes compared to traditional T-cell therapies.
Macrophage cell therapy can become an attractive example of a cell therapy, with numerous potential applications, among them cancer therapy.
While T-cell based therapies so successful for the treatment of hematological malignancies! have yet failed to demonstrate effectiveness in the treatment of solid tumors, macrophages are a key component of the tumor microenvironment (TME), and in principle they are capable of killing solid tumor cells.
However, wildtype macrophages commonly respond to the…
TECHNISCHE UNIVERSITAET DRESDEN
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