CORDIS Project
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This project focuses on developing a high-throughput assay to identify genetic changes in leukemia using mouse models. It aims to differentiate between critical and non-critical genes to improve targeted therapies and reduce treatment toxicity for patients with acute lymphoblastic leukemia.
Within a highly successful research environment, we will develop a state-of the-art high throughput functional in vivo oncogenicity assay, using mouse bone marrow transplant models of leukaemia to conclusively identify the important genetic changes involved in the development and progression of cancer.
This study will focus on B-lineage acute lymphoblastic leukaemia (ALL), for which there is a wealth of knowledge on the biology of the disease.
Our aim will be to differentiate between driver and…
UNIVERSITY OF NEWCASTLE UPON TYNE
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