CORDIS Project
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This project investigates the role of Interferon Regulatory Factor 4 (IRF4) in melanoma and lymphocyte cancers. It aims to understand the gene regulatory networks controlled by IRF4, which could lead to new therapeutic targets for melanoma treatment.
Interferon regulatory factor 4 (IRF4) is a transcriptional regulator with critical roles in lymphocyte development and function.
We have recently shown that cells from a poor-prognosis subtype of lymphoma and multiple myeloma show non-oncogene addiction to IRF4.
Using integrative genome-wide strategies, we have identified the gene regulatory program that IRF4 controls in these cancers.In several studies, high IRF4 expression was consistently observed also in cells derived from the melanoma type…
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