CORDIS Project
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This project investigates the origins and mechanisms of malignant rhabdoid tumours in children, focusing on the role of the SMARCB1 gene. By utilizing advanced genomic and imaging techniques, it aims to uncover the factors that contribute to cancer development and explore potential targeted therapies.
Childhood cancers are believed to be rooted in aberrant development, a notion supported by their (i) generally low mutational burden, (ii) high prevalence of single (often epigenetic) driver events and (iii) occurrence during confined developmental periods.
Yet, the exact origins of developmental tumours remain one of the principal enigmas of pediatric oncology. A prime example are malignant rhabdoid tumours (MRTs): they are astoundingly genomically simple but extremely deadly childhood cancers…
FUNDACIO PRIVADA PER A LA RECERCA I LA DOCENCIA SANT JOAN DE DEU
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Spain, Barcelona
Type: Research institute
Activity type: Research Organisations
SME: No
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