CORDIS Project
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This project focuses on understanding the DNA damage caused by oncogenes in lymphoid malignancies. By identifying genomic lesions that allow tumor cells to tolerate stress, the research aims to improve treatment strategies for leukemia and lymphoma.
Recurrent oncogenic chromosomal rearrangements are a hallmark of lymphoid malignancies and are considered to be the driving force in tumor survival and progression.
While oncogenes typically induce uncontrolled proliferation, they also induce metabolic stress and constitutive DNA damage.
Hence, at the time of diagnosis tumor genomes are typically highly mutated.
Not surprisingly, forced expression of an oncogene in healthy cells results in oncogenic stress leading to apoptosis or cell cycle arre…
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