CORDIS Project
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This project explores overdominance in genetics, where individuals with two different alleles have a fitness advantage over those with one. It aims to test a theory on spontaneous mutations and screen for overdominant alleles in natural populations using yeast and Daphnia as model organisms.
Overdominance occurs when individuals carrying two different alleles at a specific locus have higher Darwinian fitness than both homozygotes, who carry only one allele.
It is involved in a range of observations in genetics and evolution (e.g. genetic diversity, inbreeding depression, heterosis) and has been controversial for over a century.
Empirical studies on the frequency of spontaneous mutations causing overdominance are scarce and there has been no systematic effort to screen for overdomin…
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS
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