CORDIS Project
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This project investigates the role of invariant natural killer T cells in human obesity and cancer. It aims to understand their physiological functions and the impact of omental lipids, potentially leading to new immunotherapies for obesity-related complications and malignancies.
Invariant natural killer T (iNKT) cells play crucial roles in protection against cancer in murine models.
We have described large populations of iNKT cells in the human omentum, which until now were thought to be rare in humans.
Omental iNKT cells display potent cytotoxicity against autologous tumors in vitro however, in patients with obesity and cancer, iNKT cells are depleted.
This fellowship seeks to answer many questions which have remained elusive since the discovery of iNKT cells 15 years…
THE PROVOST, FELLOWS, FOUNDATION SCHOLARS & THE OTHER MEMBERS OF BOARD, OF THE COLLEGE OF THE HOLY & UNDIVIDED TRINITY OF QUEEN ELIZABETH NEAR DUBLIN
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