CORDIS Project
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This project aims to develop advanced methods for detecting and characterizing small protein aggregates involved in Alzheimer’s and Parkinson’s diseases. By using fluorescence techniques, it seeks to understand the toxic oligomers present in these conditions, potentially leading to early diagnostic tools and therapeuti…
Small soluble protein aggregates play a key role in the onset and spreading of Alzheimer’s and Parkinson’s diseases.
However, which oligomers are present in human disease and which are toxic remains unknown because ultrasensitive methods do not exist to detect and characterise the low concentration of oligomers, which are highly heterogeneous in size and structure.
To address this problem we will develop fluorescence based methods to detect and characterise individual oligomers to measure the ol…
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