CORDIS Project
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This research focuses on understanding myelin plasticity and its role in cognitive aging. The project aims to uncover the mechanisms behind oligodendrocyte dysfunction and its impact on memory, potentially leading to new therapeutic strategies for brain health.
Myelin, an oligodendrocyte membrane spirally wrapped around axons, has only recently been appreciated to be a plastic structure, which constantly remodels in response to experience.
Myelin plasticity is based on proliferation and maturation of oligodendrocyte precursor cells (OPCs) to form new myelinating oligodendrocytes (oligodendrogenesis), in conjunction with remodelling of myelin that is already established.
The cellular and molecular mechanisms governing myelin plasticity and how it contri…
WEIZMANN INSTITUTE OF SCIENCE
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