CORDIS Project
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This project explores the oligomerization of G protein-coupled receptors, specifically the GABAB receptor, to understand its functional significance in cell communication. It aims to develop advanced microscopy techniques to analyze these receptors in primary neurons.
G protein-coupled receptors (GPCRs) are key players in cell communication and represent the largest class of drug targets.
However, GPCR lead compound development has suffered from a low success rate the last 10 years, likely because these receptors are more complex than initially thought. GPCRs are known to form dimers and higher oligomers with specific properties, but the physiological relevance of this oligomerization remains elusive in native tissues.
Deciphering the precise functional conse…
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS
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