CORDIS Project
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This project investigates how master transcription factors and chromatin interact to regulate gene activity during animal development and stress responses. By using innovative assays and microscopy, it aims to understand the formation and function of transcriptional condensates in the model organism Caenorhabditis eleg…
Master transcription factors (TFs) cooperate with chromatin in regulating genomic activity in animal development and stress response.
Local clustering of TFs into dense, sub-micrometer size condensates is emerging as a key feature of transcriptional regulation.
This includes intranuclear condensates formed by pioneer TFs during development, transient clusters of RNA Polymerase II complex and nuclear stress bodies formed during a heat shock.
Despite the ubiquity of these assemblies, we know littl…
INSTYTUT BIOLOGII DOSWIADCZALNEJ IM. M. NENCKIEGO POLSKIEJ AKADEMII NAUK
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