CORDIS Project
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This project investigates how tissue homeostasis is maintained in the oesophagus by studying progenitor cell behavior. It aims to determine if the traditional model of stem and transit amplifying cells applies or if an alternative model is more accurate, with implications for understanding cancer development in this ti…
Stem cells are generally thought to maintain homeostasis in adult tissues, producing committed progenitor cells that in turn generate terminal differentiated cells.
Although adult stem cells have been studied intensively, far less is known about how they function in vivo to maintain tissue homeostasis.
It has long been assumed that adult tissues are maintained by long lived, slow cycling, self renewing stem cells which generate a population of committed progenitors known as “transit amplifying”…
MEDICAL RESEARCH COUNCIL
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