CORDIS Project
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This project investigates how obesity-induced lipotoxicity and endoplasmic reticulum stress impact the hypothalamus, aiming to understand their role in energy balance regulation. It seeks to identify potential therapeutic strategies targeting these stress mechanisms to prevent or reverse obesity and its related metabol…
It is well established that metabolically relevant organs such as adipose tissue, pancreatic beta cells, liver and skeletal muscle develop endoplasmic reticulum (ER) stress under conditions of obesity induced lipotoxicity.
Here, the applicant will investigate if/how the hypothalamus is affected by lipotoxicity and ER stress in the context of obesity* Scientific Hypotheses:1.
Obesity is associated with lipotoxicity and ER stress in the hypothalamus.2.
Hypothalamic ER stress may contribute to the…
UNIVERSIDADE DE SANTIAGO DE COMPOSTELA
UNIVERSIDAD DE SANTIAGO DE COMPOSTELA
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