CORDIS Project
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This project investigates the role of different vascular niches in the bone marrow that influence hematopoietic stem cell behavior and leukemia progression. It employs advanced genetic models and imaging techniques to understand the interactions between blood vessels and stem cells.
Research of the bone marrow (BM) hematopoietic stem cell (HSC) niche has long been the study of mesenchymal cell populations.
Only recently, distinct vascular niches have been identified to balance HSC activation and quiescence.
Whereas arterioles together with sympathetic nerves and NG2+Nesbright cells form a niche for quiescent HSC, actively proliferating HSC are closely located to sinusoidal vessels and LepR+Neslow cells.
However, it is still elusive how different blood vessels interact with…
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