CORDIS Project
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This project investigates how nutrient fluctuations influence hormone levels and cell signaling, particularly focusing on the mechanistic target of rapamycin (mTOR) pathway. It aims to understand the role of nutrient sensing in diseases like cancer and diabetes, using genetically engineered mice to explore physiologica…
A major role of metabolic alterations in the development of several human diseases, as diabetes, cancer and in the onset of ageing is becoming increasingly evident.
This has a deep impact for human health due to the alarming increase in nutrient intake and obesity in the last decades.
Fundamental aspects of how aberrant nutrient fluctuations trigger deregulated hormone levels and endocrine signals have been elucidated, being a prime example the phenomenon of insulin resistance.
In contrast, how…
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