CORDIS Project
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This project investigates the molecular mechanisms regulating the bacterial initiator protein DnaA, which is crucial for DNA replication. By exploring how nutrient availability affects DnaA activity, the research aims to enhance understanding of bacterial growth control in various applications, including industry and m…
DNA replication is a fundamental biological process enabling the transmission of genetic information to progeny.
In bacteria, its initiation involves a set of genes whose regulation is critical to ensure genome stability, both under optimal conditions and in response to environmental cues, including changes in nutrient availability.
The highly conserved bacterial initiator protein DnaA has been proposed as a primary target for the nutritional control of DNA replication.
Nevertheless, surprisingl…
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