CORDIS Project
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This project aims to understand the regulatory roles of nucleoporins in gene expression by developing advanced imaging techniques. By labeling and tracking nucleoporins in living cells, the research seeks to uncover their interactions and functions at the molecular level.
Nucleoporins are major building blocks of the nuclear pore complex (NPC).
In addition to their role in the nucleocytoplasmic transport, a subset of nucleoporins have additional gene regulatory roles.
They can bind chromatin and chromatin modifiers, either directly at the NPC or in the nucleoplasm, leading to gene repression or activation.
Due to a lack of techniques that allow mapping spatial and temporal heterogeneities of individual proteins with high precision, the molecular mechanisms underl…
EUROPEAN MOLECULAR BIOLOGY LABORATORY
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