CORDIS Project
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This project investigates the mechanisms of cell plasticity, focusing on how chromatin changes influence the transition from totipotency to differentiation in mouse embryos. It aims to uncover the role of heterochromatin in maintaining developmental potential, which could inform strategies for epigenetic reprogramming…
A fundamental question in biology is to understand the mechanisms underlying cell plasticity.
Such plasticity or potency is essential to form multiple cell types upon differentiation.
In mammals, upon fertilization and fusion of the gametes –two highly differentiated cells- intense chromatin remodeling and epigenetic reprogramming, the reversion into an undifferentiated state, are essential to restore full developmental potency (totipotency).
Subsequent development and differentiation are accomp…
HELMHOLTZ ZENTRUM MUENCHEN DEUTSCHES FORSCHUNGSZENTRUM FUER GESUNDHEIT UND UMWELT GMBH
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France, Illkirch Graffenstaden
Type: Research institute
Activity type: Research Organisations
SME: No
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