CORDIS Project
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This project examines the role of ribosomal DNA in genomic stability and cancer. It investigates how damage to these DNA regions contributes to malignancy and aims to identify mechanisms for potential therapeutic strategies.
DNA lesions can impose serious threats to genome integrity and cell viability.
Whereas DNA damage may occur anywhere in the genome, it is increasingly recognized that certain genomic loci rich in repetitive sequences display increased susceptibility to damage and are linked to chromosomal rearrangements and malignancy.
Clusters of ribosomal DNA gene (rDNA) repeats, present on five different chromosomes, constitute the most heavily transcribed area of the human genome and are organized in a nucle…
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