CORDIS Project
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This project investigates the roles of small RNA and ARGONAUTE proteins in gene regulation within plants. It aims to uncover new functions of these proteins in the nucleus, which could enhance understanding of plant development and antiviral defense mechanisms.
Plants and animals use small (s)RNA to control many developmental and physiological processes. sRNAs associate with ARGONAUTE (AGO) proteins as part of RNA-induced-silencing-complexes (RISC) to regulate gene expression at the transcriptional or post-transcriptional levels.
The major effector of post-transcriptional gene silencing (PTGS) in Arabidopsis thaliana, AGO1, has been mainly implicated in cytoplasmic processes including cleavage (or ’slicing’) and translational repression of sRNA target…
EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH
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