CORDIS Project
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This research investigates the role of the nucleolus in regulating lifespan and metabolic health through conserved signaling pathways. It aims to uncover how nucleolar size and function relate to longevity and immunity in various species, including humans.
Research over the last few decades has revealed that animal life span is malleable and regulated by conserved metabolic signaling pathways, including reduced insulin/IGF signaling, mTOR, mitochondrial function, dietary restriction, and signals from the reproductive system.
Whether these various pathways converge on common processes, however, has remained elusive.We recently discovered the nucleolus to be a crucial focal point of regulation in all these pathways.
The nucleolus is a subnuclear org…
MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV
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