CORDIS Project
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This project aims to identify and understand post-translational modifications of proteins, specifically N-terminal acetylation, which plays a crucial role in regulating various biological functions. By exploring the enzymes responsible for these modifications, the research seeks to uncover their impact on cellular proc…
In mammalian cells, N-terminal (Nt) acetylation is one of the most abundant protein modifications.
It is catalysed by N-terminal acetyltransferases (NATs) and mostly occurs co-translationally.
However, in contrast to the defined co-translational NATs, post-translational NATs which have crucial regulatory roles are mostly unexplored.
Distinct peptide hormones regulate appetite, metabolism, sexual behaviour and pain, and their biological activity is critically modulated by post-translational Nt-ac…
UNIVERSITETET I BERGEN
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