CORDIS Project
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This project aims to identify the receptors and signals involved in the development of osteoclasts, which are responsible for bone loss in diseases like osteoporosis and arthritis. It focuses on the role of the OSCAR receptor and its ligands in regulating osteoclastogenesis.
Pathological bone loss (osteolysis), the process whereby osteoclasts erode mineralised bone matrix, remains an unresolved challenge in the pathology of osteolytic diseases, such as osteoporosis, rheumatoid arthritis (RA) and osteolytic bone cancers.
Identification of the receptors involved in osteoclast development (osteoclastogenesis) is currently a high priority in osteoclast research.
The goal of this research is to identify and understand the receptors and ligands regulating osteoclastogenes…
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