CORDIS Project
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This project focuses on the role of specific protein kinases in regulating integrin activity, which is crucial for cell adhesion and signaling in cancer progression. By studying these mechanisms, the project aims to identify new therapeutic targets for cancer treatment.
Integrins represent a family of cell adhesion receptors mediating cell interaction with the extracellular matrix ligands.
Their ligand-binding activity is tightly regulated and, when defective, gives rise to thrombosis or inflammation and contributes to cancer progression.
To date, the key steps of integrin activation in response to both extracellular and intracellular signals are well described, however, the counteracting processes resulting in receptor inactivation remain incompletely understo…
TURUN YLIOPISTO
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