CORDIS Project
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This project aims to map the structural variations of nuclear pore complexes across different human cell types. By combining advanced imaging and mass spectrometry techniques, it seeks to understand how these structures adapt to fulfill specific cellular functions.
The nuclear pore complex (NPC) is one of the most intricate components of eukaryotic cells and is assembled from ~30 Nucleoporins (Nups) in an unknown manner.
Here I present an experimental result driven hypothesis, namely that the composition of the NPC varies across human cell types.
As a consequence, the nucleocytoplasmic transport system might be fine-tuned to fulfill specific tasks in various cell types and to adjust the composition of the nuclear compartment.
In the research proposed here,…
EUROPEAN MOLECULAR BIOLOGY LABORATORY
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