CORDIS Project
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This project investigates the structure and function of nuclear pore complexes, specifically the basket structure that influences transport and gene expression. By developing new tools for structural analysis, the research aims to enhance understanding of how these complexes operate within the nuclear envelope.
Nuclear pore complexes (NPCs) are gatekeepers at the nuclear envelope, mediating traffic between the nucleus and cytoplasm.
Unlike simpler protein channels that insert into a single lipid bilayer, NPCs can remodel the outer and inner nuclear membranes to form a specialized pore in the nuclear envelope.
High-resolution models of the symmetric NPC core have transformed our understanding of NPC architecture.
In contrast, we know little about the NPC basket, a prominent structure on the nucleoplasmi…
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