CORDIS Project
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This research project focuses on developing new anti-cancer drug candidates targeting the lactate dehydrogenase 5 enzyme, which is crucial for the survival of hypoxic solid tumors. By inhibiting this enzyme, the project aims to reduce the energy supply to cancer cells, potentially decreasing their invasive and metastat…
The purpose of this research project is the development of preclinical anti-cancer drug candidates able to fight hypoxic solid tumours, which are normally resistant to chemotherapy and radiotherapy.
Highly invasive tumour cells are characterized by a metabolic switch, known as the Warburg effect, from “normal” oxidative phosphorylation to an increased anaerobic glycolysis.
This ensures a sufficient energy supply from glucose, even in hypoxic environments.
One of the key enzymes involved in anaer…
UNIVERSITA DI PISA
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