CORDIS Project
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This project aims to enhance the expansion of hematopoietic stem cells from cord blood to improve their use in blood and marrow transplantation. By identifying novel regulatory factors that promote stem cell proliferation, the project seeks to enable successful transplants for adult patients who currently lack suitable…
Blood and marrow transplantation (BMT) has been used successfully to treat malignant blood disorders and genetic diseases.
Although BMT has been effective, problems remain, for example lack of suitable donors and engraftment failure.
Cord blood (CB) contains hematopoietic stem cells (HSC) that can be used to transplant children.
However, there are too few HSC in most CB samples to reliably engraft adult patients following BMT.
Development of HSC expansion prior to transplantation would allow suc…
MAX IV Laboratory, Lund University
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