CORDIS Project
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The project focuses on developing a cell therapy for Duchenne Muscular Dystrophy by transferring a human artificial chromosome into patient-derived cells. It aims to create immortalized mesoangioblasts to facilitate effective transplantation and evaluate therapeutic outcomes in animal models.
This project aims to develop an effective cell therapy for Duchenne Muscular Dystrophy (DMD).
To reach this goal we plan to transfer a human artificial chromosome containing the whole dystrophin locus into dystrophic mesoangioblasts.
As the transfer is inefficient and requires selection, it is impossible to use primary cells that would undergo senescence during selection.
Therefore we need to reversibly immortalize DMD patient mesoangioblasts by the combined use of lentiviral vectors expressing…
THE UNIVERSITY OF MANCHESTER
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LONDON
Type: University / higher education
Activity type: Higher or Secondary Education Establishments
SME: No
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