CORDIS Project
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This project explores the mechanisms of T cell activation and signaling in the immune response. It aims to understand the role of specific proteins in T cell function and their implications for immune regulation and potential cancer therapies.
The current paradigm of T cell function in the immune response is that T cells recognize antigen through the T cell antigen receptor (TCR) which transduces signals to the cytoplasm by way of cytosolic priming and effector tyrosine kinases.
The TCR acts in a monovalent fashion is crosslinked by its antigen/MHC (pMHC) ligand, causing TCR triggering.
However, our more recent data indicate that the TCR is organized in pre-existing oligomers, and therefore it might not require crosslinking, and that…
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