CORDIS Project
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The NOVARA project aims to create hypoallergenic variants of Amb a 1, the primary allergen in ragweed pollen, for use in allergy immunotherapy. By engineering these variants, the project seeks to minimize side effects while maintaining effectiveness in treating allergies.
Ragweed pollen allergy is a new and steadily growing health problem in Europe.
The aim of the proposed Marie Curie Fellowship, NOVARA, is to engineer hypoallergenic Amb a 1, the major allergen of ragweed pollen, for use as new vaccine candidates for allergen-specific immunotherapy (SIT).
Since conventional SIT may induce undesired IgE-mediated side-effects, there is a need for well defined proteins with reduced or abolished IgE binding capacity and retained T cell-activating capacity, as substit…
PARIS-LODRON-UNIVERSITAT SALZBURG
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