CORDIS Project
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This project explores the role of gamma delta T cells in recognizing stress-related molecules in various tissues. It focuses on the endothelial cell protein C receptor as a target for these immune cells, aiming to enhance understanding of their function in immune responses.
T lymphocytes bearing gamma delta T cell receptors (TCR) make crucial contributions to tissue-surveillance of infection and non-microbial stress.
Although these cells may recognise dysregulated tissues via their activating NKG2D receptor, we remain very ignorant of stress-related molecules that may bind the gamma/delta TCR directly.
Much work has focussed on peripheral blood gamma delta T cells expressing Vgamma9-Vdelta2 TCRs.
Recently however, several Vgamma9-Vdelta2-negative clones were isolat…
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