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The NOVA project develops a new class of semi-synthetic polymyxins aimed at reducing the toxicity associated with traditional polymyxin antibiotics. These next-generation antibiotics target multi-drug-resistant Gram-negative bacterial infections, offering a safer and more effective treatment option for patients facing…
In the NOVA ERC PoC project, we present a novel class of semi-synthetic polymyxins as an innovative solution to address the inherent toxicity of the polymyxins family of antibiotics.
We here disclose the first candidate compounds of this novel family of antibiotics with potential for use as front-line treatment for multi-drug-resistant Gram-negative bacterial infections.Due to antimicrobial resistance (AMR), a resurgence in the use of polymyxin antibiotics has occurred over the last decade, desp…
UNIVERSITEIT LEIDEN
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