CORDIS Project
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This project explores how the identity and function of macrophages are determined by their genomic organization and environmental signals. By integrating advanced techniques, it aims to reveal the mechanisms behind macrophage specialization and plasticity, with implications for understanding immune responses.
Macrophages are highly specialized cells widely distributed in tissues and active both as immune effectors and as housekeeping phagocytes responsible for maintenance of tissue integrity.
Macrophages display a striking heterogeneity that reflects a complex interplay between different micro-environmental signals provided by various tissues (as well as by microbial and endogenous stress signals), and a robust differentiation program that determines macrophage identity.Terminal differentiation depen…
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