CORDIS Project
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This project explores the dynamics of NF-kB, a key regulator of inflammation, at both single-cell and population levels. It aims to understand how oscillations in NF-kB activity affect gene expression and could inform treatments for diseases like cancer and autoimmune disorders.
NF-kB is a family of transcription factors that coordinately control hundreds of genes involved in many steps of inflammatory processes, from microbial killing to cancer.
When inflammatory stimuli hit the cell surface, NF-kB undergoes several cycles of nucleus-to-cytoplasm translocations, resulting in oscillations of nuclear NF-kB concentrations and activity.At single cell level, live imaging and mathematical modeling suggest that NF-kB oscillations are selected over other non-oscillatory dynami…
UNIVERSITA VITA-SALUTE SAN RAFFAELE
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