CORDIS Project
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This project investigates the role of Nogo-A, a protein that inhibits nerve fiber growth, in the recovery from spinal cord injuries and strokes. It aims to understand the molecular mechanisms behind Nogo-A and its receptors to enhance recovery strategies for nerve damage.
Repulsive guidance cues for growing axons and factors inhibiting neurite growth are increasingly recognized as key players for nerve fiber growth and plasticity in the developing and adult nervous system.
The first neurite growth inhibitory factor discovered in the context of axonal regeneration in the adult central nervous system (CNS) was the membrane protein Nogo-A.
Inactivation of Nogo-A, e.g. by neutralizing antibodies, after spinal cord injury, brain injury or stroke leads to improved func…
University of Zurich
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