CORDIS Project
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This project investigates the role of endothelial cells in lung adenocarcinoma, focusing on how specific gene mutations influence immune responses in tumors. By reprogramming these cells, the aim is to enhance the effectiveness of immunotherapy in cold tumors, potentially improving treatment outcomes for lung cancer pa…
Lung cancer is the leading cause of cancer-related deaths worldwide.
Currently, immunotherapy (IT) is the standard of care for the treatment of some subtypes, with only nominal success. IT works best in inflamed “hot” tumors and is often ineffective in immune cell-desert “cold” tumors.
In KRAS-mutated lung adenocarcinoma -LUAD, the most frequent type of lung cancer- the presence of a mutation in the STK11/LKB1 gene is linked to a cold tumor, while the co-occurrence of a TP53 mutation corresponds…
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