CORDIS Project
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This project explores the regulation of nitric oxide production by focusing on arginine availability rather than nitric oxide synthase activity. It aims to uncover mechanisms for therapeutic applications in systemic disorders.
Nitric oxide (NO) is an essential signalling molecule for diverse physiological and disease processes.
The current paradigm of how NO production is regulated focuses at the level of nitric oxide synthase (NOS), with respect to substrate and co-factor availability and the precise spatial and temporal arrangement of protein complexes.
However, the respective unique or combined genetic deficiencies of the NOS isoforms exhibit relatively modest phenotypes in mice.
Moreover, approaches targeted at…
WEIZMANN INSTITUTE OF SCIENCE
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