CORDIS Project
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This research investigates the role of protein S-nitrosylation in inflammation-related cancers, particularly lung cancer. It aims to characterize the S-nitrosylated proteome and explore the mechanisms regulating this process to understand its impact on cancer development.
Chronic inflammation represents a major pathologic basis for many human cancers.
Nitric oxide (NO) production is a hallmark of inflammation, and may play a significant role in inflammation-associated cancers. S-nitrosylation, the covalent attachment of an NO group to the thiol side chain of cysteine is a common mechanism for dynamic, post-translational regulation of most or all main classes of protein.
Indeed, protein S-nitrosylation and denitrosylation have emerged as integral components of sig…
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