CORDIS Project
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This project investigates the role of argininosuccinic acid lyase in nitric oxide production, which is crucial for various physiological processes. By studying its impact on nitric oxide signaling in the central nervous system, the project aims to develop therapeutic strategies for conditions related to nitric oxide de…
Nitric oxide (NO) is an essential signaling molecule for diverse physiological and disease processes.
The current paradigm of NO regulation focuses at the level of nitric oxide synthase (NOS).
However, the respective unique or combined genetic deficiencies of the NOS isoforms exhibit relatively modest phenotypes in mice.
Moreover, approaches targeted at modulating NOS activities have not successfully translated into therapy.
All NOSs isoforms use arginine as the sole substrate for NO producti…
WEIZMANN INSTITUTE OF SCIENCE
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